Leiomyosarcoma of the Gallbladder

Leiomyosarcoma of the gallbladder is a rare entity constituting about 1.4 per 1000 gallbladder malignancies. Few cases were reported in literatures most of which were in females in their sixth decade of life. This case represents an addition to this series. A case of a 50 years old, otherwise healthy, female patient, admitted with non-specific clinical presentation suggestive of cholecystitis was reported. The ultrasound impression was fatty hepatomegaly and cholecystitis with cholelithiasis. She was operated upon. A pedunculated polypoid mass (1.5 x 1.3 cm) was incidentally discovered on the gross examination of the cholecystectomy specimen. Histopathological examination revealed spindle cell proliferation. The histological appearance of the mass examined was unquestionably malignant tumor of possible mesenchymal origin. Immunhistochemistry clearly demonstrated that the tumor on hand was a true sarcoma of smooth muscle origin (Positive for vimentin, smooth muscle actin and Desmin).